| NCAAF | 11/11 18:00 | 1 | Monmouth Scots v Knox Prairie Fire | L | 42-7 | |
| NCAAF | 11/04 18:00 | 1 | Knox Prairie Fire v Lawrence Vikings | W | 48-28 | |
| NCAAF | 10/28 18:00 | 1 | Knox Prairie Fire v Cornell Rams | L | 21-28 | |
| NCAAF | 10/21 18:00 | 1 | Grinnell Pioneers v Knox Prairie Fire | W | 7-14 | |
| NCAAF | 10/14 18:00 | 1 | Illinois College Blueboys v Knox Prairie Fire | L | 61-7 | |
| NCAAF | 10/07 18:00 | 1 | Knox Prairie Fire v Ripon Red Hawks | L | 3-10 | |
| NCAAF | 09/30 19:00 | 1 | Knox Prairie Fire v Lake Forest Foresters | L | 0-50 | |
| NCAAF | 09/16 19:00 | 1 | Chicago Maroons v Knox Prairie Fire | L | 63-0 | |
| NCAAF | 09/09 18:00 | 1 | Knox Prairie Fire v Beloit Buccaneers | W | 31-14 | |
| NCAAF | 09/02 23:00 | 1 | Eureka Red Devils v Knox Prairie Fire | L | 41-16 | |
| NCAAF | 11/12 18:00 | 1 | Knox Prairie Fire v Monmouth Scots | L | 0-56 | |
| NCAAF | 11/05 18:00 | 1 | Cornell Rams v Knox Prairie Fire | W | 27-31 |